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The mechanism of action underlying ketamine’s antidepressant effects

The mechanism of action underlying ketamine’s antidepressant effects Ketamine affects multiple neurotransmitter systems, including the opioidergic, monoaminergic, glutamatergic, and muscarinic systems, as well as substance P and sigma receptors. Early work by Skolnick and colleagues implicated the glutamatergic system in depression [7], and research over the past three decades further implicated the NMDA receptor in …

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Crystal ketamine powder

The effects of ketamine on depression and who can benefit from it

Psychedelic drug therapy has put ketamine in the spotlight Ketamine is an anesthetic used to sedate both humans and pets, and it’s a favorite of party goers seeking a psychedelic high. Now it’s also the subject of an enormous amount of interest as a fast-acting treatment for depression and other serious mental health conditions. Despite …

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They Didn’t Know ketamine works for depression, try it now

Jeff Winograd didn’t know an adult life without depression. Since he was 20 years old, he had tried almost every antidepressant on the market. But he says, “The depression was just unchanging. Ketamine works for depression By the period he was 45 years old, by then a father of two small children and a struggling-at-the-time …

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