The mechanism of action underlying ketamine’s antidepressant effects
The mechanism of action underlying ketamine’s antidepressant effects Ketamine affects multiple neurotransmitter systems, including the opioidergic, monoaminergic, glutamatergic, and muscarinic systems, as well as substance P and sigma receptors. Early work by Skolnick and colleagues implicated the glutamatergic system in depression [7], and research over the past three decades further implicated the NMDA receptor in …
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